Explaining the unexplained: new genetic mutations in unexplained premature ovarian insufficiency

Explaining medically unexplained symptoms.

Patients with medically unexplained symptoms comprise from 15% to 30% of all primary care consultations. Physicians often assume that psychological factors account for these symptoms, but current theories of psychogenic causation, somatization, and somatic amplification cannot fully account for common unexplained symptoms. Psychophysiological and sociophysiological models provide plausible medi...

Explaining sudden unexplained death.

Explaining the Unexplained Causes of Syncope

Determining the cause of recurrent unexplained syncope remains a clinical challenge and a permanent quest. Guidelines and multiple studies emphasize that a clear deductive method based on a thorough interrogation and examination can usually disclose the etiology of syncope in the majority of cases (2). Nonetheless, in daily clinical practice, applying a simple comprehensive diagnostic approach ...

Explaining the unexplained in clinical infectious diseases: looking forward.

We examined the need to improve our ability to explain the unexplained in clinical infectious diseases, primarily through improvements in diagnostic technology. Part of the motivation for this effort came from an Emerging Infectious Disease Program (funded by the National Center for Infectious Diseases, Centers for Disease Control and Prevention [CDC]) to conduct surveillance for unexplained de...

new hopes for the treatment of primary ovarian insufficiency/ premature ovarian failure

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